Yanmeng Wang

Dedicated candidate with eight years of lab experience in cellular and molecular biology, specialized at cancer research and innovative therapeutic strategies, and eager to put analytical and problem-solving skills to practice in professional setting. Skilled at gathering and analyzing data for research with keen eye for accuracy. Reliable with strong leadership skills for mentoring and supervising students. Flexible with solid adaptability for working in dynamic environment. Proficient in in cell-based and quantitative assays, such as in vitro assays, RT-qPCR, lentiviral transduction, RNAseq, western blotting and flow cytometry. Detail-oriented team player with strong organizational skills. Ability to handle multiple projects simultaneously with a high degree of accuracy.

• Obtained China Scholarschip Council (CSC) Grant, a national scholarship for performing PhD training abroad.
• Obtained Emmanuel Van Der Schueren Grant from Kom Op Tegen Kanker for finishing my PhD training.
• Achieved Third Young Speaker Award for Best Oral Presentation at the 2022 Annual Meeting of the Belgium Association for Cancer Research (BACR)

• Cellular Biology

Culturing multiple myeloma cell lines, nature killer cell lines and bone marrow stromal cells • Lentivirus transduction • Small interfering RNA (siRNA) transfection • Electrotransfection • Flow cytometry • Functional oncoassays.

• Molecular Biology

DNA/RNA/protein extraction and quantification • Primer design • Real-time RCR • Western blot • Enzyme-linked immunosorbent spot assay • Gel electrophoresis • Metabolomics analysis.

• Murine experiments and human patient samples

Mice handling • Intraperitoneal injection • Intravenous injection • Bone marrow cells isolation, purification and culturing • Isolation, selection and culturing of myeloma cells and stromal cells from the patients’ bone marrow.

• IT

Microsoft Office • Graphpad Prism • FlowJo • Image Studio Lite • Photoshop • Image J • Adobe Illustrator • Basic R.

• Yanmeng Wang, Catharina Muylaert, Arne Wyns, Philip Vlummens, Kim De Veirman, Karin Vanderkerken, Esther Zaal, Celia Berkers, Jérome Moreaux, Elke De Bruyne, and Eline Menu. S-adenosylmethionine biosynthesis is a targetable metabolic vulnerability in multiple myeloma. Haematologica, 2024 Jan 1; 109(1): 256–271. Q1 in Hematology, IF = 10.1
• Yanmeng Wang, Kim De Veirman, Karin Vanderkerken, Catharina Olsen, Eline Menu* and Elke De Bruyne*. Targeting MAT2A alters the methylation landscape and DNA damage response in multiple myeloma, leading to novel combination strategies. (In preparation)
• Yanmeng Wang, Niels Vandewalle, Kim De Veirman, Karin Vanderkerken, Eline Menu*, and Elke De Bruyne*. Targeting mTOR signaling pathways in multiple myeloma: biology and implication for therapy. Cell Communication and Signaling, 2024; 22: 320. Q1 in Cell Biology, IF = 8.2
• Rui Teng, Yanmeng Wang, Nan Lv, Dan Zhang, Ramone A. Williamson, et al. Corrigendum to “Hypoxia Impairs NK Cell Cytotoxicity through SHP-1-Mediated Attenuation of STAT3 and ERK Signaling Pathways”. J Immunol Res. 2021 Feb 25; 2021:3625084. Shared first author. Q2 in Immunology, IF = 3.5
• Niels Vandewalle, Hatice Satilmis, Emma Verheye, Rong Fan, Yanmeng Wang, Timo W M De Groof, Jessica Bridoux, Tessa Kerre, Nathan De Beule, Ann De Becker, Elke De Bruyne, Eline Menu, Karin Vanderkerken, Karine Breckpot, Nick Devoogdt, Kim De Veirman. AXL- specific single domain antibodies show diagnostic potential and anti-tumor activity in Acute Myeloid Leukemia. Theranostics, 2024; 14(7): 2656–2674. IF = 12.4
• Fang Wang, Inge Oudaert, Chenggong Tu, ..., Yanmeng Wang, Rong Fan et al. System Xc- inhibition blocks bone marrow-multiple myeloma exosomal crosstalk, thereby countering bortezomib resistance. Cancer letters. 2022 Jun 1; 535:215649. IF = 9.1
• Dan Zhang, Rui Teng, Nan Lv, Lei Lei, Yanmeng Wang, et al. A novel CD2 staining–based flow cytometric assay for assessment of natural killer cell cytotoxicity. J Clin Lab Anal. 2020 Dec;34(12): e23519. IF = 2.6
• Dan Zhang, Kim De Veirman, Rong Fan, ..., Yanmeng Wang, Lei Lei, et al. ER stress arm XBP1s plays a pivotal role in proteasome inhibition-induced bone formation. Stem Cell Res Ther. 2020 Nov 30;11(1):516. IF = 7.1
• Dan Zhang, Rong Fan, Li Lei, Lei Lei, Yanmeng Wang, Nan Lv, Ping Chen, Ramone A Williamson, Baiyan Wang, Jinsong Hu. Cell cycle exit during bortezomib-induced osteogenic differentiation of mesenchymal stem cells was mediated by Xbp1s-upregulated p21Cip1 and p27Kip1. J Cell Mol Med, 2020 Aug; 24(16):9428-9438. IF = 4.3
• Lingjuan Huang, Yanmeng Wang, Ju Bai, Yun Yang, Fangxia Wang, Yuandong Feng, Ru Zhang, Fangmei Li, Peihua Zhang, Nan Lv, Lei Lei, Jinsong Hu, Aili He. Blockade of HSP70 by VER-155008 synergistically enhances bortezomib-induced cytotoxicity in multiple myeloma. Cell Stress & Chaperones, 2020 Mar;25(2):357-367. IF = 3.3