Summary
Overview
Work History
Education
Skills
Academic Age
Hindex
Current Position
Further Education
Employments
Grants and Fundings
Teaching
Students Supervision
Patents
Science Activities
Review Activity
Personal Information
Awards
Conferences
Research IDs
Hobby
Accomplishments
Timeline
Generic
Mona Omar Mohsen

Mona Omar Mohsen

Associate Professor of Tumor Immunology/Immunotherapy
Bern

Summary

Focused on cancer immunology and immunotherapy, with research centered on developing innovative therapeutic strategies such as cancer vaccines, immune enhancers, and checkpoint inhibitors. Successfully applied these approaches to solid tumors, including breast cancer, melanoma, and head and neck carcinoma. Specialized expertise in virus-like nanoparticles and their unique properties, pioneering novel cancer vaccine platforms.

Overview

2025
2025
years of professional experience
10
10
years of post-secondary education
3
3
Languages

Work History

Principal Investigator and a Group Leader

University of Bern
1 2021 - Current
  • Focused on advancing cancer immunology through innovative therapeutic strategies, including cancer vaccines, immune enhancers, and checkpoint inhibitors, with a specialization in targeting solid tumors such as breast cancer, melanoma, and head and neck carcinoma. Leads a research team utilizing virus-like particles (VLPs) as a core platform to enhance immune response and therapeutic efficacy. In addition to cancer immunotherapy, actively involved in developing vaccines against infectious diseases such as MERS and COVID, a vaccine targeting chronic inflammation and aging, and exploring opportunities to use murine spleens as organoids to test vaccine efficacy—an area aligned with Integrated Health Biology (IHB) at Roche.
  • Oversees multiple research projects in cancer immunology and immunotherapy, including targeting mucosal sites for therapeutic vaccines against head and neck cancer, investigating the role of gamma delta T cells with VLPs, designing a single-chain fusion vaccine against melanoma, and developing a vaccine targeting IgE as a promising approach in solid tumor immunotherapy. Actively integrates AI-based histology to assess the effectiveness of VLP-based vaccines, enhancing precision in evaluating therapeutic outcomes.
  • Recent achievements include a publication in iScience detailing the development of a tetravalent nanovaccine for HPV-associated head and neck carcinoma, demonstrating tumor inhibition through dendritic and T cell activation—laying the foundation for an independent research career within the Cell Publishing Group. Additionally, led a pioneering study on the efficacy of intranodal injection of immune activators (naked VLPs), showcasing a novel approach with significant antitumor potential in preclinical tumor models.
  • Responsible for mentoring two PhD students and three master’s students, providing hands-on laboratory guidance and cultivating critical thinking in cancer immunology. Actively engaged in teaching and curriculum development to prepare the next generation of scientists for careers in immunotherapy research.
  • Experienced in managing complex research projects from conception to impactful outcomes, with Study Director (LTK2) certification. Collaborates closely with AI-supported pathologists and uses Visiopharm for advanced multiplexing analysis to enhance therapeutic vaccine research. Extensive international collaborations with research teams at the University of Oxford, in the US, Latvia, and Lausanne further enrich the research environment, bringing together diverse expertise to address critical challenges in cancer.


  • Highlighted Publications:
  • Romano Josi, Daniel E. Speiser, Simone de Brot, Anne-Cathrine Vogt, Eva M. Sevick-Muraca, Genrich V. Tolstonog, Martin F. Bachmann, Mona O. Mohsen. A tetravalent nanovaccine that inhibits growth of HPV-associated head and neck carcinoma via dendritic and T cell activation. iScience. Doi:10.1016/j.isci.2023.109439. Accepted 4 March 2024.
  • Josi R, Ogrina A, Rothen D, Balke I, Casaramona AS, de Brot S, Mohsen MO. Intranodal Injection of Immune Activator Demonstrates Antitumor Efficacy in an Adjuvant Approach. Vaccines (Basel). 2024 Mar 26;12(4):355. doi: 10.3390/vaccines12040355. PMID: 38675737; PMCID: PMC11054762.

Postdoctoral Researcher

University of Bern
01.2019 - 01.2020
  • Immediately after completing a PhD, awarded a Post-Doctoral Research Award (PDRA) grant from the Qatar Foundation. This grant led to a publication in the Journal of Immunotherapy of Cancer (JITC) and facilitated new collaborations with international institutes, ultimately opening NIH funding opportunities.
  • A Highlighted Publication: Mohsen MO, Speiser DE, Michaux J, Pak H, Stevenson BJ, Vogel M, Inchakalody VP, de Brot S, Dermime S, Coukos G, Bassani-Sternberg M, Bachmann MF. Bedside formulation of a personalized multi-neoantigen vaccine against mammary carcinoma. J Immunotherapy Cancer. 2022 Jan;10(1):e002927. doi: 10.1136/jitc-2021-002927. PMID: 35017147.
  • Postdoctoral research focused on developing an in situ cancer vaccine with demonstrated efficacy in murine melanoma models. This work was published in the Journal of Immunotherapy of Cancer (JITC) and funded by the Swiss Cancer League, which also highlighted the project in its online communications. This project led to a first patent filed through Unitectra, titled “European Patent Application No. 22152314.5 with Unitectra (University of Bern).”
  • A Highlighted Publication: Mohsen MO, Heath M, Kramer MF, Velazquez TC, Bullimore A, Skinner MA, Speiser DE, Bachmann MF. In situ delivery of nanoparticles formulated with micron-sized crystals protects from murine melanoma J Immunotherapy Cancer. 2022 Sep;10(9):e004643. doi: 10.1136/jitc-2022-004643. PMID: 36100311; PMCID: PMC9472128.

Doctoral Student

University of Oxford
01.2015 - 01.2018
  • During PhD research, developed a precision platform for virus-like particle (VLP)-based cancer vaccines, utilizing immunopeptidomics and whole exome sequencing to identify melanoma-specific T-cell epitopes (including non-mutated germ-line and mutated neo-epitopes) in the B16F10 melanoma model. These epitopes were prioritized through bioinformatics and validated with in vitro T-cell assays. Selected epitopes were coupled to Qβ-VLP loaded with B-type CpGs, a potent immune-stimulator, using bio-orthogonal Cu-free click chemistry. Customized VLP-based vaccine cocktails were then created and tested for efficacy in murine models with aggressive B16F10p33 melanomas.
  • In parallel, the efficacy of CuMVTT-VLP (Cucumber Mosaic Virus VLP with a tetanus-toxoid universal T cell epitope) displaying the p33 epitope and formulated with microcrystalline tyrosine (MCT®) as an adjuvant was assessed, targeting specific T-cell responses in the B16F10p33 melanoma model. The depot-forming effect of MCT with and without CuMVTT-VLP was examined, and MCT’s adjuvant potential was compared to commonly used adjuvants, including Alum and B-type CpGs.
  • Highlighted Publications:
  • Mohsen MO, Vogel M, Riether C, Muller J, Salatino S, Ternette N, Gomes AC, Cabral-Miranda G, El-Turabi A, Ruedl C, Kundig TM, Dermime S, Knuth A, Speiser DE, Bachmann MF. Targeting Mutated Plus Germline Epitopes Confers Pre-clinical Efficacy of an Instantly Formulated Cancer Nano-Vaccine. Front Immunol. 2019 May 15;10:1015. doi: 10.3389/fimmu.2019.01015. PMID: 31156619; PMCID: PMC6532571.
  • Mohsen MO, Heath MD, Cabral-Miranda G, Lipp C, Zeltins A, Sande M, Stein JV, Riether C, Roesti E, Zha L, Engeroff P, El-Turabi A, Kundig TM, Vogel M, Skinner MA, Speiser DE, Knuth A, Kramer MF, Bachmann MF. Vaccination with nanoparticles combined with micro-adjuvants protects against cancer. J Immunother Cancer. 2019 Apr 26;7(1):114. doi: 10.1186/s40425-019-0587-z. Erratum in: J Immunother Cancer. 2019 May 23;7(1):137. PMID: 31027511; PMCID: PMC6485085.

Master Student

Qatar University
01.2014 - 01.2015
  • Master’s research focused on investigating novel pyridine derivatives for their anti-cancer effects across breast (MCF-7), ovarian, and colon cancer cell lines to determine if their activity was cell-specific, tumor-type specific, or broadly effective. Among the compounds studied, derivative 91 exhibited the highest cytotoxicity against MCF-7 breast cancer cells, reducing cell viability by 40% at a concentration of 20 µM. Further studies identified compound 9a as the most potent derivative against MCF-7 cells expressing wild-type p53, significantly inhibiting cell proliferation. Data indicated that compound 9a induces apoptosis in MCF-7 cells by targeting p53 and p21, with minimal toxicity toward normal breast cell lines (MCF-12). This research has been published.

Senior Clinical Researcher

Weill Cornell Medical College-Doha
01.2014 - 01.2015
  • Served as the coordinator for a project titled Cross-Cultural Experience of Pregnancy Loss, under the supervision of Dr. Susie Kilshaw. Responsibilities included collecting, organizing, and maintaining data for clinical studies; assisting with IRB preparation for ethical approval; obtaining informed consent from participants; and acquiring clinical specimens and data as required by the protocol. Collaborated closely with lab technicians and investigators to ensure availability and preparation of requested specimens, while managing inventory and disposal of study materials. Acted as a liaison between clinical sites and WCMC-Q, reviewing and verifying data by comparing source documents with electronic records. Conducted participant interviews throughout the study and attended regular meetings with CRCs, investigators, and senior staff. This project ultimately culminated in a publication.

Education

Doctor of Philosophy (PhD) - Clinical Immunology

University of Oxford
University Of Oxford
10.2015 - 10.2018

Master of Science - Cancer Biology

Qatar University
Qatar
09.2013 - 06.2015

Bachelor of Science - Biomedical Sciences

Qatar University
Qatar
09.1997 - 06.2002

Skills

  • Advanced Research and Experimental Design

  • Strategic Experimental Planning and Execution

  • In-Depth Data Analysis and Interpretation

  • Clear and Impactful Scientific Communication

  • Collaborative and Cross-Disciplinary Research

  • Expertise in Grant and Manuscript Development

  • Intellectual Property (IP) Management for Research Innovations

  • Skilled Scientific Writing and Documentation

  • Effective Team Leadership and Research Collaboration

  • Strategic Problem Solving in Complex Research Environments

  • Strong Leadership and Mentorship in Academic and Research Settings

Academic Age

6.5 years

Hindex

28

Current Position

Associate Professor of Tumor Immunology/Immunotherapy, University of Bern

Further Education

  • One-year international study program you completed was a collaboration between Harvard Medical School and Qatar Foundation, in partnership with Harvard University, during 2016-2017. This program was designed to provide advanced training and global perspectives in medical sciences, offering exposure to Harvard's rigorous standards in medical education and research methodologies. Participants engaged in specialized coursework and were encouraged to develop expertise in key areas of medicine, fostering skills relevant to international healthcare advancements and collaborations.
  • Completed a summer internship from July to September 2015 in the research group of Prof. Mien-Chie Hung at The University of Texas MD Anderson Cancer Center, as part of the QRLP Internship program. Assigned to various cancer biology projects, including investigating the role of GSK3β inactivation in promoting the oncogenic functions of EZH2 and enhancing H3K27 methylation in human breast cancers. Gained proficiency in key techniques such as western blotting, cell culture, transfection, and cloning, while actively participating in seminars and journal clubs to expand knowledge and stay updated on the latest advancements in cancer biology.

Employments

Associate Professor, University of Bern, 2024
Principal Investigator and Group Leader, University of Bern, 2021–ongoing
Privatdozent (PD), University of Bern, 2021
Postdoctoral Researcher, University of Bern, 2019–2020
Doctoral Student, University of Oxford, UK, 2015–2018
Master’s Student, Qatar University, 2013–2015
Senior Clinical Researcher, Weill Cornell Medical College, Doha, Qatar, 2014–2015
Lab Technologist, Hamad Medical Corporation, Doha, Qatar, 2004–2007

Grants and Fundings


  • NIH parent R01, Personalized, antigen-directed immunotherapy delivered to lymph nodes, 2023-2027
  • Ju biläumsstiftung von Swiss Life, Preclinical efficacy of a personalized therapeutic vaccine to prevent postoperative metastases in mammary carcinoma, 2023-2024
  • Swiss Federal Institute for Forest, Snow and Landscape Research, Co-PI, Nanoparticle Trafficking in Trees Visualized by Virus-Like Particles, 2023-2024
  • Swiss Cancer League, KFS-5246-02-2021, Co-investigator, Intratumor immunotherapy using TLR7/8 loaded nanoparticles formulated with an inflammasome activating micron-sized particulate adjuvant (MCT) in solid murine tumor models, 2020-2023
  • Qatar Foundation, PDRA4-0118-18002, Lead investigator, Development and exploration of a novel personalized breast-cancer vaccine based on virus-like particles by incorporating tumor-specific T-cell epitopes, 2019-2021
  • Allergy Therapeutics PLC, Lead investigator, Developing a novel immune-enhancer for melanoma using MCT adjuvant, 2018-2021
  • Master and PhD scholarship, Qatar Foundation (QRLP), 2015-2018

Teaching

  • Multidisciplinary Centre for Infectious Diseases (MCID), University of Bern, 2024-ongoing
  • Immunology courses I and II, University of Bern, 2019-ongoing
  • Problem-based solving, Qatar University, 2020
  • Summer school for immunology/Cancer immunology & immunotherapy, Anhui Agricultural University, 2019
  • Immunology seminars, RIA, University of Bern, 2019
  • Immunology, Nuffield Department of Medicine, University of Oxford, 2016-2018

Students Supervision

Ongoing projects: 

  • PhD thesis, Personalized, antigen-directed immunotherapy delivered to lymph nodes, 2023
  • PhD thesis, Development of a therapeutic multi-target VLP-based vaccine against HPV-associated head and neck cancer, 2020
  • Master thesis, Developing AI-driven histology methods to predict therapeutic outcomes following VLP vaccination in solid tumor, 2024
  • Master thesis, A VLP-based vaccine in Allergy-Oncology leverages virus-like particles, September 2024
  • Master thesis, Development of a fusion VLP-gp75 based vaccine targeting melanoma, 2024


Completed thesis: 

  • Master thesis, Comparison between germline and mutated VLP-based vaccines, 2023
  • Master thesis, Depletion of Tregs enhances T cells reactivity, 2022
  • Master thesis, Development of virus-like particles-based vaccines against MERS virus., 2020
  • Master thesis, Comparison of the immunological properties between rod and round shaped CCMV virus-like particles, 2019

Patents

European Patent Application No. 22152314.5, Unitectra (University of Bern), A new patent is currently under filing with Unitecra (University of Bern)

Science Activities

A board member of Female Empowerment in Life Sciences (FELS) Network, University of Bern

Review Activity

  • Vaccines
  • Journal of Translational Medicine
  • Nature Communications
  • Nature Reviews Bioengineering
  • Viruses
  • Cells

Personal Information

  • Date of Birth: 07/16/78
  • Marital Status: Married. Swiss citizenship under processing.

Awards

  • Vaccines Young Investigator award, Vaccines Journal (MDPI), 2024
  • Poster award, SSAI Annual Congress, 2019
  • Master research project award, Qatar University, 2015

Conferences

  • Switzerland, The 2nd International Electronic Conference on Vaccines, A session chair and organiser, 2024
  • Switzerland, SSAI 2024 Geneve, Oral presentation, 2024
  • Switzerland, SSAI 2023 Bern, organizer/speaker/moderator, 2023
  • Czech Republic, EAACI, Poster, 2022
  • Switzerland, WIRM, Poster, 2021
  • Switzerland, SSAI ANNUAL CONGRESS, Oral presentation, 2021
  • Switzerland, WIRM, Poster, 2019
  • Switzerland, SSAI ANNUAL CONGRESS, Poster, 2019
  • Switzerland, Modern vaccines adjuvants and delivery system, Oral presentation, 2019
  • Switzerland, Virus-like particles vaccines, Oral presentation, 2018
  • Qatar, Cancer immunotherapy workshop 2018, Oral presentation, 2018
  • Singapore, Virus-like particles & nano-particle vaccines, Oral presentation, 2017
  • Italy, 11th ENII Summer School, Poster, 2016

Research IDs

0000-0003-3510-9148, https://scholar.google.com/citations?user=ndhfo9oAAAAJ&hl=en

Hobby

Outside the lab, I enjoy belly dancing as both a sport and a creative way to relieve stress, which helps me maintain balance and well-being.

Accomplishments

  • In just six years of academia, I have published over 50 original and review papers, including 18 as the corresponding author. Many of my publications have appeared in high-impact journals such as Journal of Immunotherapy of Cancer, iScience (Cell Press), Allergy, New England Journal of Medicine and NPJ Vaccines (Nature Publishing Group).
  • I am the founder and CEO of DeepVax GmbH, a research-based biomedical company and spin-off University of Bern. Established in July 2018 and headquartered in Zürich, Switzerland, DeepVax focuses on the discovery, development, manufacturing, and marketing of innovative therapies for cancer treatment and chronic diseases. I have filed a European Patent Application (No. 22152314.5) through Unitectra.
  • My personal achievements explain the delay in my career progression as a mother of four children. My son, 27, holds an MBA from Aberdeen University, and my three daughters (25, 21, and 20) are pursuing studies in International Business and Medicine in Qatar. Having founded my family, I am fully dedicated now to my research career and not focused on family expansion. I pursued my master’s and PhD studies later in life due to traditional cultural expectations in Qatar, which led to my marriage at the age of 18.
  • During the COVID-19 pandemic in 2020, I was appointed as the head of the Corona Preclinical Development Team in Prof. Bachmann's lab, where I led the team with dedication and contributed as the corresponding author on several publications. This experience reinforced my commitment to advancing scientific research and public health initiatives.

Timeline

Postdoctoral Researcher

University of Bern
01.2019 - 01.2020

Doctor of Philosophy (PhD) - Clinical Immunology

University of Oxford
10.2015 - 10.2018

Doctoral Student

University of Oxford
01.2015 - 01.2018

Master Student

Qatar University
01.2014 - 01.2015

Senior Clinical Researcher

Weill Cornell Medical College-Doha
01.2014 - 01.2015

Master of Science - Cancer Biology

Qatar University
09.2013 - 06.2015

Bachelor of Science - Biomedical Sciences

Qatar University
09.1997 - 06.2002

Principal Investigator and a Group Leader

University of Bern
1 2021 - Current
Mona Omar MohsenAssociate Professor of Tumor Immunology/Immunotherapy