Jawaharlal Nehru Centre for Advanced Scintific Research
1 2019 - 03.2022
Project title: Engineering conditionally replication-competent SARs CoV-2 viral molecular clones and evaluation of cross-variant neutralization: Constructed viral molecular clones of SARs-CoV-2 lacking two crucial structural genes (M and N). The viral clones proliferate only in engineered cell-lines (Vero-E6, BHK-21, Calu-3) expressing these missing genes
Supervisor: Prof Udaykumar Ranga
Junior research fellow
Jawaharlal Nehru Centre for Advanced Scintific Research
01.2017 - 01.2019
Project title: Population-based research studies to understand disease dynamics towards effective management, Prevention and treatment of HIV/AIDS, including co-morbidities and co-infections: Developed TILDA to characterize HIV-1 latent reservior. The assay is applicable to the diverse genetic subtypes of HIV-1.
Supervisor: Prof Udaykumar Ranga
Education
Ph.D. - Health Sciences
Ugent
Ghent, Belgium
04.2001 -
M.Sc. Biotechnology -
DBT Bhimtal, Kumaun University Nainital, Uttarakhand
Nainital, Uttarakhand
08.2015 - 05.2017
Bachelor of Science -
Punjabi University, Patiala, Punjab
Patiala, Punjab
05.2012 - 05.2015
Skills
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Courses
2023
Virus Evolution and Molecular Epidemology (VEME) : Phylogenetic inference module
HIV Reservoir Characterization Workshop: HCRC Ghent
2022
Applied Statistic: from Basics to Regression Modelling
Conferences
2023
Poster- Determination of HIV-1 Subtype, Prediction of Co-receptor Tropism and Drug Resistance Mutations by Partial Sequencing of HIV Env and Pol in the 2000HIV Cohort at 10th HIV Cure Symposium, Ghent
Poster- Determination of HIV-1 Subtype and Prediction of Co-receptor Tropism by Partial Sequencing of HIV Env in the 2000HIV Cohort at VEME, Stellenbosch
2021
Poster- Engineering conditionally replication-competent (CRC) SARS-CoV-2 viral molecular clones at AFM and In-house symposium, JNCASR, Bengaluru
Publications
Mehta, K. et al. An Improved Tat/Rev Induced Limiting Dilution Assay With En-hanced Sensitivity and Breadth of Detection. Front. Immunol. 12,1-14 (2021).
Bhange, D. et al. The Evolution of Regula-tory Elements in the Emerging Promoter-Variant Strains of HIV-1 Subtype C. Front. Microbiol. 12, 3442 (2021).
Ali H, Bhange D, Mehta K, et al. An emerg-ing and variant viral promoter of HIV-1 subtype C exhibits low-level gene expres-sion noise. Retrovirology 18, 1-12 (2021).
Timeline
Junior research fellow
Jawaharlal Nehru Centre for Advanced Scintific Research
01.2017 - 01.2019
M.Sc. Biotechnology -
DBT Bhimtal, Kumaun University Nainital, Uttarakhand
08.2015 - 05.2017
Bachelor of Science -
Punjabi University, Patiala, Punjab
05.2012 - 05.2015
Ph.D. - Health Sciences
Ugent
04.2001 -
Senior research fellow
Jawaharlal Nehru Centre for Advanced Scintific Research
Summer Research Fellow at Jawaharlal Nehru Centre For Advanced Scientific Research, JNCASR BengaluruSummer Research Fellow at Jawaharlal Nehru Centre For Advanced Scientific Research, JNCASR Bengaluru
National Post-doc Fellow at Jawaharlal Nehru Centre For Advanced Scientific ResearchNational Post-doc Fellow at Jawaharlal Nehru Centre For Advanced Scientific Research
Business Development and Sales - Studentjob at Flanders-China Chamber of Commerce (FCCC)Business Development and Sales - Studentjob at Flanders-China Chamber of Commerce (FCCC)